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Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion

Macropinocytosis, the internalization of extracellular fluid and material by plasma membrane ruffles, is critical for antigen presentation, cell metabolism, and signaling. Macropinosomes mature through homotypic and heterotypic fusion with endosomes and ultimately merge with lysosomes. The molecular...

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Biol
Hauptverfasser: Dolat, Lee, Spiliotis, Elias T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004444/
https://ncbi.nlm.nih.gov/pubmed/27551056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201603030
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