An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation

BACKGROUND: Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by episodic psychosis and altered cognitive function. Despite success in identifying genetic variants associated with schizophrenia, there remains uncertainty about the causal genes involved in disease pathogene...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Hannon, Eilis, Dempster, Emma, Viana, Joana, Burrage, Joe, Smith, Adam R., Macdonald, Ruby, St Clair, David, Mustard, Colette, Breen, Gerome, Therman, Sebastian, Kaprio, Jaakko, Toulopoulou, Timothea, Pol, Hilleke E. Hulshoff, Bohlken, Marc M., Kahn, Rene S., Nenadic, Igor, Hultman, Christina M., Murray, Robin M., Collier, David A., Bass, Nick, Gurling, Hugh, McQuillin, Andrew, Schalkwyk, Leonard, Mill, Jonathan
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004279/
https://ncbi.nlm.nih.gov/pubmed/27572077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1041-x
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