A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma

Interferon-gamma (IFN-γ) is a pleiotropic cytokine that exerts anti-tumor and anti-osteoclastogenic effects. Although transcriptional and post-transcriptional regulation of IFN-γ is well understood, subsequent modifications of secreted IFN-γ are not fully elucidated. Previous research indicates that...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kanzaki, Hiroyuki, Shinohara, Fumiaki, Suzuki, Maiko, Wada, Satoshi, Miyamoto, Yutaka, Yamaguchi, Yuuki, Katsumata, Yuta, Makihira, Seicho, Kawai, Toshi, Taubman, Martin A., Nakamura, Yoshiki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004192/
https://ncbi.nlm.nih.gov/pubmed/27573075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32259
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