Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines

A variant in the breast cancer resistance protein (BCRP) gene, 421C> A is a useful biomarker for describing large inter-individual differences in the pharmacokinetics of sulfasalazine (SASP), a BCRP substrate. However, large intra-genotypic variability still exists in spite of the incorporation o...

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Vydáno v:Sci Rep
Hlavní autoři: Gotanda, Keisuke, Hirota, Takeshi, Saito, Jumpei, Fukae, Masato, Egashira, Yu, Izumi, Noritomo, Deguchi, Mariko, Kimura, Miyuki, Matsuki, Shunji, Irie, Shin, Ieiri, Ichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004159/
https://ncbi.nlm.nih.gov/pubmed/27571936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32299
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