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Valve interstitial cell tensional homeostasis directs calcification and extracellular matrix remodeling processes via RhoA signaling

AIMS: Valve interstitial cells are active and aggressive players in aortic valve calcification, but their dynamic mediation of mechanically-induced calcific remodeling is not well understood. The goal of this study was to elucidate the feedback loop between valve interstitial cell and calcification...

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Библиографические подробности
Опубликовано в: :Biomaterials
Главные авторы: Farrar, Emily J., Pramil, Varsha, Richards, Jennifer M., Mosher, Christopher Z., Butcher, Jonathan T.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003711/
https://ncbi.nlm.nih.gov/pubmed/27497058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2016.07.034
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