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Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING
Inflammatory diseases such as Aicardi–Goutières syndrome and severe systemic lupus erythematosus are generally lethal disorders that have been traced to defects in the exonuclease TREX1 (DNase III). Mice lacking TREX1 similarly die at an early age through comparable symptoms, including inflammatory...
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| Publicado no: | J Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003413/ https://ncbi.nlm.nih.gov/pubmed/25261479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401337 |
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