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Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants
HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2(S306A) mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain the serine protease domain (PD) and the regulat...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003398/ https://ncbi.nlm.nih.gov/pubmed/27571206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161526 |
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