Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants

HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2(S306A) mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain the serine protease domain (PD) and the regulat...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Gieldon, Artur, Zurawa-Janicka, Dorota, Jarzab, Miroslaw, Wenta, Tomasz, Golik, Przemyslaw, Dubin, Grzegorz, Lipinska, Barbara, Ciarkowski, Jerzy
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003398/
https://ncbi.nlm.nih.gov/pubmed/27571206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161526
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