Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells

The genome-wide depletion of 5-methylcytosines (5meCs) caused by passive dilution through DNA synthesis without daughter strand methylation and active enzymatic processes resulting in replacement of 5meCs with unmethylated cytosines is a hallmark of primordial germ cells (PGCs). Although recent stud...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Miyoshi, Norikatsu, Stel, Jente M., Shioda, Keiko, Qu, Na, Odajima, Junko, Mitsunaga, Shino, Zhang, Xiangfan, Nagano, Makoto, Hochedlinger, Konrad, Isselbacher, Kurt J., Shioda, Toshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003264/
https://ncbi.nlm.nih.gov/pubmed/27486249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610259113
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