Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease

Hydroxyurea (HU) has been used clinically to reduce the frequency of painful crisis and the need for blood transfusion in sickle cell disease (SCD) patients. However, the mechanisms underlying such beneficial effects of HU treatment are still not fully understood. Studies have indicated a weak corre...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hosseini, Poorya, Abidi, Sabia Z., Du, E, Papageorgiou, Dimitrios P., Choi, Youngwoon, Park, YongKeun, Higgins, John M., Kato, Gregory J., Suresh, Subra, Dao, Ming, Yaqoob, Zahid, So, Peter T. C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003247/
https://ncbi.nlm.nih.gov/pubmed/27512047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610435113
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