Global Cysteine-Reactivity Profiling During Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity

In the nematode, Caenorhabditis elegans, inactivating mutations in the insulin/IGF-1 receptor, DAF-2, result in a 2-fold increase in lifespan mediated by DAF-16, a FOXO-family transcription factor. Downstream protein activities that directly regulate longevity during impaired Insulin/IGF-1 signaling...

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Udgivet i:Cell Chem Biol
Main Authors: Martell, Julianne, Seo, Yong Hak, Bak, Daniel W., Kingsley, Samuel F., Tissenbaum, Heidi A., Weerapana, Eranthie
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003114/
https://ncbi.nlm.nih.gov/pubmed/27499530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.06.015
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