Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis

BACKGROUND: Data from multiple sclerosis (MS) and the MS rodent model, experimental autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent synaptopathy at the basis of the neurodegenerative damage causing irreversible disability in these disorders. This synaptopathy is characteriz...

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Bibliografiska uppgifter
I publikationen:J Neuroinflammation
Huvudupphovsmän: Gentile, Antonietta, Musella, Alessandra, Bullitta, Silvia, Fresegna, Diego, De Vito, Francesca, Fantozzi, Roberta, Piras, Eleonora, Gargano, Francesca, Borsellino, Giovanna, Battistini, Luca, Schubart, Anna, Mandolesi, Georgia, Centonze, Diego
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002118/
https://ncbi.nlm.nih.gov/pubmed/27566665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0686-4
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