Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

Mechanical cues play important roles in directing the lineage commitment of mesenchymal stem cells (MSCs). In this study, we explored the molecular mechanisms by which dynamic tensile loading (DL) regulates chromatin organization in this cell type. Our previous findings indicated that the applicatio...

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Bibliographic Details
Published in:Biophys J
Main Authors: Heo, Su-Jin, Han, Woojin M., Szczesny, Spencer E., Cosgrove, Brian D., Elliott, Dawn M., Lee, David A., Duncan, Randall L., Mauck, Robert L.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2016
Subjects:
Cell Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002070/
https://ncbi.nlm.nih.gov/pubmed/27558729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.07.006
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