Structure of Gremlin-2 in complex with GDF5 gives insight into DAN-family mediated BMP antagonism

The DAN-family, including Gremlin-1 and Gremlin-2 (Grem1 and Grem2), represents a large family of secreted BMP antagonists. However, how DAN proteins specifically inhibit BMP signaling has remained elusive. Here, we report the structure of Grem2 bound to GDF5 at 2.9 Å resolution. The structure revea...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Nolan, Kristof, Kattamuri, Chandramohan, Rankin, Scott A., Read, Randy J., Zorn, Aaron M., Thompson, Thomas B.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001929/
https://ncbi.nlm.nih.gov/pubmed/27524626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.046
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