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Members of the DAN Family are BMP Antagonists that form Highly Stable Noncovalent Dimers

Signaling of BMP ligands is antagonized by a number of extracellular proteins, including noggin, follistatin and members of the DAN family. Structural studies on the DAN family member sclerostin (a weak BMP antagonist) have previously revealed that the protein is monomeric and consists of an 8-membe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kattamuri, Chandramohan, Luedeke, David M., Nolan, Kristof, Rankin, Scott A., Greis, Kenneth D., Zorn, Aaron M., Thompson, Thomas B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509953/
https://ncbi.nlm.nih.gov/pubmed/23063586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.10.003
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