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Hypercholesterolemia induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II-induced Abdominal Aortic Aneurysms in C57BL/6 Mice
OBJECTIVE: Gain-of-function mutations of proprotein convertase subtilisin/kexin type 9 (PCSK9) lead to hypercholesterolemia. This study was to determine whether infection of normocholesterolemic mice with an adeno-associated viral vector (AAV) expressing a gain-of-function mutation of mouse PCSK9 in...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5001883/ https://ncbi.nlm.nih.gov/pubmed/27470509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307613 |
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