Učitavanje...
The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction
In response to proteasome dysfunction, mammalian cells upregulate proteasome gene expression by activating Nrf1. Nrf1 is an endoplasmic reticulum-resident transcription factor that is continually retrotranslocated and degraded by the proteasome. Upon proteasome inhibition, Nrf1 escapes degradation a...
Spremljeno u:
| Izdano u: | eLife |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2016
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5001836/ https://ncbi.nlm.nih.gov/pubmed/27528193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18357 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|