The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

In response to proteasome dysfunction, mammalian cells upregulate proteasome gene expression by activating Nrf1. Nrf1 is an endoplasmic reticulum-resident transcription factor that is continually retrotranslocated and degraded by the proteasome. Upon proteasome inhibition, Nrf1 escapes degradation a...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Koizumi, Shun, Irie, Taro, Hirayama, Shoshiro, Sakurai, Yasuyuki, Yashiroda, Hideki, Naguro, Isao, Ichijo, Hidenori, Hamazaki, Jun, Murata, Shigeo
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2016
Matèries:
Biochemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001836/
https://ncbi.nlm.nih.gov/pubmed/27528193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18357
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