Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region

Pathogenic bacteria such as Haemophilus influenzae, a major cause of lower respiratory tract diseases, must cope with a range of electrophiles generated in the host or by endogenous metabolism. Formaldehyde is one such compound that can irreversibly damage proteins and DNA through alkylation and cro...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Couñago, Rafael M., Chen, Nathan H., Chang, Chiung-Wen, Djoko, Karrera Y., McEwan, Alastair G., Kobe, Bostjan
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001606/
https://ncbi.nlm.nih.gov/pubmed/27307602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw543
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