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Design of Association Studies with Pooled or Un-pooled Next-Generation Sequencing Data
Most common hereditary diseases in humans are complex and multifactorial. Large scale genome-wide association studies based on SNP genotyping, have only identified a small fraction of the heritable variation of these diseases. One explanation may be that many rare variants (a minor allele frequency,...
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| Pubblicato in: | Genet Epidemiol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5001557/ https://ncbi.nlm.nih.gov/pubmed/20552648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20501 |
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