Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases

BACKGROUND: Subfertility affects approximately 15% of all couples, and a severe male factor is identified in 17% of these couples. While the etiology of a severe male factor remains largely unknown, prior gonadotoxic treatment and genomic aberrations have been associated with this type of subfertili...

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Udgivet i:Hum Reprod Update
Main Authors: Mulder, Callista L., Zheng, Yi, Jan, Sabrina Z., Struijk, Robert B., Repping, Sjoerd, Hamer, Geert, van Pelt, Ans M.M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001497/
https://ncbi.nlm.nih.gov/pubmed/27240817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humupd/dmw017
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