Biochemical and structural analysis of the interaction between β-amyloid and fibrinogen

The majority of patients with Alzheimer disease (AD) suffer from impaired cerebral circulation. Accumulating evidence suggests that fibrinogen, the main protein component of blood clots, plays an important role in this circulatory dysfunction in AD. Fibrinogen interacts with β-amyloid (Aβ), forming...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zamolodchikov, Daria, Berk-Rauch, Hanna E., Oren, Deena A., Stor, Daniel S., Singh, Pradeep K., Kawasaki, Masanori, Aso, Kazuyoshi, Strickland, Sidney, Ahn, Hyung Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000847/
https://ncbi.nlm.nih.gov/pubmed/27389717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-705228
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