Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice

KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) has been reported to cause hepatic fat loss. However, the action mechanisms of KMUP-1 in obesity-induced steatohepatitis remains unclear. This study elucidated the steatohepatitis via matrix metallopeptidase 9 (MMP-9) and tumo...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Wu, Bin-Nan, Kuo, Kung-Kai, Chen, Yu-Hsun, Chang, Chain-Ting, Huang, Hung-Tu, Chai, Chee-Yin, Dai, Zen-Kong, Chen, Ing-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000741/
https://ncbi.nlm.nih.gov/pubmed/27548140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17081345
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