TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

BACKGROUND: High fat diet (HFD) induces insulin resistance in various tissues, including the vasculature. HFD also increases plasma levels of TNF-α, a cytokine that contributes to insulin resistance and vascular dysfunction. Considering that the enzyme phosphatase and tension homologue (PTEN), whose...

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Bibliografske podrobnosti
izdano v:Cardiovasc Diabetol
Main Authors: da Costa, Rafael Menezes, Neves, Karla Bianca, Mestriner, Fabíola Leslie, Louzada-Junior, Paulo, Bruder-Nascimento, Thiago, Tostes, Rita C.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Original Investigation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000486/
https://ncbi.nlm.nih.gov/pubmed/27562094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-016-0443-0
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