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Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke

An important contributor to brain ischemia is known to be extracellular acidosis, which activates acid-sensing ion channels (ASICs), a family of proton-gated sodium channels. Lines of evidence suggest that targeting ASICs may lead to novel therapeutic strategies for stroke. Investigations of the rol...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Li, Ming-Hua, Leng, Tian-Dong, Feng, Xue-Chao, Yang, Tao, Simon, Roger P., Xiong, Zhi-Gang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000083/
https://ncbi.nlm.nih.gov/pubmed/27402850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.713636
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