A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

Thiopurine therapy, commonly used in autoimmune conditions, can be complicated by life-threatening leukopenia. This leukopenia is associated with genetic variation in TPMT (encoding thiopurine S-methyltransferase). Despite a lower frequency of TPMT mutations in Asians, the incidence of thiopurine-in...

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Gepubliceerd in:Nat Genet
Hoofdauteurs: Yang, Suk-Kyun, Hong, Myunghee, Baek, Jiwon, Choi, Hyunchul, Zhao, Wanting, Jung, Yusun, Haritunians, Talin, Ye, Byong Duk, Kim, Kyung-Jo, Park, Sang Hyoung, Park, Soo-Kyung, Yang, Dong-Hoon, Dubinsky, Marla, Lee, Inchul, McGovern, Dermot P B, Liu, Jianjun, Song, Kyuyoung
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999337/
https://ncbi.nlm.nih.gov/pubmed/25108385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3060
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