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Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden
We characterized clinically occurring and novel mutations in the β subunit of RNA polymerase in Clostridium difficile (CdRpoB), conferring rifamycin (including rifaximin) resistance. The Arg(505)Lys substitution did not impose an in vitro fitness cost, which may be one reason for its dominance among...
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| Udgivet i: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4997883/ https://ncbi.nlm.nih.gov/pubmed/27381389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01137-16 |
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