Discovery of Antischistosomal Drug Leads Based on Tetraazamacrocyclic Derivatives and Their Metal Complexes

Praziquantel (PZQ) is the only drug available for the treatment of schistosomiasis, and since its large-scale use might be associated with the onset of resistance, new antischistosomal drugs should be developed. A series of 26 synthetic tetraazamacrocyclic derivatives and their metal complexes were...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Khan, M. O. Faruk, Keiser, Jennifer, Amoyaw, P. N. A., Hossain, Mohammad F., Vargas, Mireille, Le, Justin G., Simpson, Natalie C., Roewe, Kimberly D., Freeman, TaRynn N. Carder, Hasley, Travis R., Maples, Randall D., Archibald, Stephen J., Hubin, Timothy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997856/
https://ncbi.nlm.nih.gov/pubmed/27324765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00778-16
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