Aspartate-based CXCR4 receptor binding of cross-bridged tetraazamacrocyclic copper(II) and zinc(II) complexes

The CXCR4 chemokine receptor is implicated in a number of diseases including HIV infection and cancer development and metastasis. Previous studies have demonstrated that configurationally restricted bis-tetraazamacrocyclic metal complexes are high-affinity CXCR4 antagonists. Here, we present the syn...

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Publicado no:Chemistry
Main Authors: Maples, Randall D., Cain, Amy N., Burke, Benjamin P., Silversides, Jon D., Mewis, Ryan, D’huys, Thomas, Schols, Dominique, Linder, Douglas P., Archibald, Stephen J., Hubin, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224883/
https://ncbi.nlm.nih.gov/pubmed/27458983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201601468
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