Identification of therapeutic targets applicable to clinical strategies in ovarian cancer

BACKGROUND: shRNA-mediated lethality screening is a useful tool to identify essential targets in cancer biology. Ovarian cancer (OC) is extremely heterogeneous and most cases are advanced stages at diagnosis. OC has a high response rate initially, but becomes resistant to standard chemotherapy. We p...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Kim, Marianne K., Caplen, Natasha, Chakka, Sirisha, Hernandez, Lidia, House, Carrie, Pongas, Georgios, Jordan, Elizabeth, Annunziata, Christina M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997769/
https://ncbi.nlm.nih.gov/pubmed/27558154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2675-5
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