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Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening

BACKGROUND: Non-invasive prenatal testing (NIPT) identifies fetal aneuploidy by sequencing cell-free DNA in the maternal plasma. Pre-symptomatic maternal malignancies have been incidentally detected during NIPT based on abnormal genomic profiles. This low coverage sequencing approach could have pote...

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Detalhes bibliográficos
Publicado no:BMC Med
Main Authors: Cohen, Paul A., Flowers, Nicola, Tong, Stephen, Hannan, Natalie, Pertile, Mark D., Hui, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997750/
https://ncbi.nlm.nih.gov/pubmed/27558279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-016-0667-6
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