Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model

Several lines of evidence suggest that neuregulin 1 (NRG1) signaling may influence cognitive function and neuropathology in Alzheimer’s disease (AD). To test this possibility, full-length type I or type III NRG1 was overexpressed via lentiviral vectors in the hippocampus of line 41 AD mouse. Both ty...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Xu, Jiqing, de Winter, Fred, Farrokhi, Catherine, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Cook, Jonathan, Jin, Xin, Masliah, Eliezer, Lee, Kuo-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997345/
https://ncbi.nlm.nih.gov/pubmed/27558862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31692
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