The Overexpression of TDP-43 Protein in the Neuron and Oligodendrocyte Cells Causes the Progressive Motor Neuron Degeneration in the SOD1 G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

The recent investigation suggested that the TDP-43 protein was closely related to the motor neuron degeneration in amyotrophic lateral sclerosis (ALS), but the pathogenesis contributed to motor neuron degeneration largely remained unknown. Therefore, we detected the alteration of TDP-43 expression a...

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Udgivet i:Int J Biol Sci
Main Authors: Lu, Yi, Tang, Chunyan, Zhu, Lei, Li, Jiao, Liang, Huiting, Zhang, Jie, Xu, Renshi
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997058/
https://ncbi.nlm.nih.gov/pubmed/27570488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.15938
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