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Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

Morphine and its pharmacological derivatives are the most prescribed analgesics for moderate to severe pain management. However, chronic use of morphine reduces pathogen clearance and induces bacterial translocation across the gut barrier. The enteric microbiome has been shown to play a critical rol...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Banerjee, Santanu, Sindberg, Gregory, Wang, Fuyuan, Meng, Jingjing, Sharma, Umakant, Zhang, Li, Dauer, Patricia, Chen, Chi, Dalluge, Joseph, Johnson, Timothy, Roy, Sabita
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996771/
https://ncbi.nlm.nih.gov/pubmed/26906406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2016.9
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