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Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

Morphine and its pharmacological derivatives are the most prescribed analgesics for moderate to severe pain management. However, chronic use of morphine reduces pathogen clearance and induces bacterial translocation across the gut barrier. The enteric microbiome has been shown to play a critical rol...

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Bibliografske podrobnosti
izdano v:Mucosal Immunol
Main Authors: Banerjee, Santanu, Sindberg, Gregory, Wang, Fuyuan, Meng, Jingjing, Sharma, Umakant, Zhang, Li, Dauer, Patricia, Chen, Chi, Dalluge, Joseph, Johnson, Timothy, Roy, Sabita
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996771/
https://ncbi.nlm.nih.gov/pubmed/26906406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2016.9
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