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Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1

During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the placenta, causing health problems for both the mother and fetus. The specific adherence is mediated by the VAR2CSA protein, which binds to placental chondroitin sulfate (CS) on chondroitin sulfate proteoglycans (C...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Ayres Pereira, Marina, Mandel Clausen, Thomas, Pehrson, Caroline, Mao, Yang, Resende, Mafalda, Daugaard, Mads, Riis Kristensen, Anders, Spliid, Charlotte, Mathiesen, Line, E. Knudsen, Lisbeth, Damm, Peter, G. Theander, Thor, R. Hansson, Stefan, A. Nielsen, Morten, Salanti, Ali
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996535/
https://ncbi.nlm.nih.gov/pubmed/27556547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005831
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