Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is induced in airways by virus and may mediate asthmatic airway remodeling. We sought to evaluate if genetic variants and early life lower respiratory infections jointly affect asthma risk. METHODS: We included Latino children, adolescents, and y...

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Publicado en:PLoS One
Main Authors: Cho, Seong H., Min, Jin-Young, Kim, Dong Young, Oh, Sam S., Torgerson, Dara R., Pino-Yanes, Maria, Hu, Donglei, Sen, Saunak, Huntsman, Scott, Eng, Celeste, Farber, Harold J., Rodriguez-Cintron, William, Rodriguez-Santana, Jose R., Serebrisky, Denise, Thyne, Shannon M., Borrell, Luisa N., Williams, L. Keoki, DuPont, William, Seibold, Max A., Burchard, Esteban G., Avila, Pedro C., Kumar, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996454/
https://ncbi.nlm.nih.gov/pubmed/27556405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157848
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