Engagement of SLAMF3 enhances CD4(+) T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus

Signaling lymphocytic activation molecule family 3 (SLAMF3/Ly9) is a coregulatory molecule implicated in T-cell activation and differentiation. Systemic lupus erythematosus (SLE) is characterized by aberrant T-cell activation and compromised IL-2 production, leading to abnormal regulatory T-cell (Tr...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Comte, Denis, Karampetsou, Maria P., Kis-Toth, Katalin, Yoshida, Nobuya, Bradley, Sean J., Mizui, Masayuki, Kono, Michihito, Solomon, Julie R., Kyttaris, Vasileios C., Tsokos, George C.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995972/
https://ncbi.nlm.nih.gov/pubmed/27482100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605081113
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