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Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death
Cardiorespiratory failure is the most common cause of sudden unexplained death in epilepsy (SUDEP). Genetic autopsies have detected “leaky” gain-of-function mutations in the ryanodine receptor-2 (RyR2) gene in both SUDEP and sudden cardiac death cases linked to catecholaminergic polymorphic ventricu...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4995941/ https://ncbi.nlm.nih.gov/pubmed/27482086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605216113 |
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