The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection

Coxiella burnetii, the etiological agent of Q fever in humans, is an intracellular pathogen that replicates in an acidified parasitophorous vacuole derived from host lysosomes. Generation of this replicative compartment requires effectors delivered into the host cell by the Dot/Icm type IVb secretio...

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Udgivet i:Infect Immun
Main Authors: Weber, Mary M., Faris, Robert, van Schaik, Erin J., McLachlan, Juanita Thrasher, Wright, William U., Tellez, Andres, Roman, Victor A., Rowin, Kristina, Case, Elizabeth Di Russo, Luo, Zhao-Qing, Samuel, James E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995899/
https://ncbi.nlm.nih.gov/pubmed/27324482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01554-15
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