The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection

Coxiella burnetii, the etiological agent of Q fever in humans, is an intracellular pathogen that replicates in an acidified parasitophorous vacuole derived from host lysosomes. Generation of this replicative compartment requires effectors delivered into the host cell by the Dot/Icm type IVb secretio...

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Detaylı Bibliyografya
Yayımlandı:Infect Immun
Asıl Yazarlar: Weber, Mary M., Faris, Robert, van Schaik, Erin J., McLachlan, Juanita Thrasher, Wright, William U., Tellez, Andres, Roman, Victor A., Rowin, Kristina, Case, Elizabeth Di Russo, Luo, Zhao-Qing, Samuel, James E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995899/
https://ncbi.nlm.nih.gov/pubmed/27324482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01554-15
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