The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma

The Hippo effector YAP has recently been identified as a potent driver of embryonal rhabdomyosarcoma (ERMS). Most reports suggest that the YAP paralogue TAZ (gene symbol WWTR1) functions as YAP but, in skeletal muscle, TAZ has been reported to promote myogenic differentiation, whereas YAP inhibits i...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Mohamed, Abdalla, Sun, Congshan, De Mello, Vanessa, Selfe, Joanna, Missiaglia, Edoardo, Shipley, Janet, Murray, Graeme I, Zammit, Pete S, Wackerhage, Henning
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2016
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995731/
https://ncbi.nlm.nih.gov/pubmed/27184927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4745
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