Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

The intracellular Raf-Erk signaling pathway is activated during neural stem cell (NSC) proliferation, and neuronal and astrocytic differentiation. A key question is how this signal can evoke multiple and even opposing NSC behaviors. We show here, using a constitutively active Raf (ca-Raf), that Raf-...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rhee, Yong-Hee, Yi, Sang-Hoon, Kim, Joo Yeon, Chang, Mi-Yoon, Jo, A-Young, Kim, Jinyoung, Park, Chang-Hwan, Cho, Je-Yoel, Choi, Young-Jin, Sun, Woong, Lee, Sang-Hun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995508/
https://ncbi.nlm.nih.gov/pubmed/27554447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32025
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