Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus

PURPOSE: Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine monophosphate response element-binding protein (CREB)/brain-derived neurotrophic factor (BDN...

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Publicado en:Int Neurourol J
Autores principales: Shin, Mal-Soon, Kim, Tae-Won, Park, Sang-Seo, Ko, Il-Gyu, Kim, Chang-Ju, Kim, Mia, Roh, Su Yeon, Kim, Kwang Taek, Kim, Khae Hawn
Formato: Artigo
Lenguaje:Inglês
Publicado: Korean Continence Society 2019
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606934/
https://ncbi.nlm.nih.gov/pubmed/31260611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5213/inj.1938103.052
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