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Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains

NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability. Functional NMDA receptors require two copies of the GluN1 subunit coassembled with GluN2 (and/or GluN3) subunits into a heteromeric...

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Bibliografiset tiedot
Julkaisussa:J Neurosci
Päätekijät: Wilding, Timothy J., Lopez, Melany N., Huettner, James E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995299/
https://ncbi.nlm.nih.gov/pubmed/27559165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0345-16.2016
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