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The sphingosine‐1‐phosphate analogue, FTY‐720, promotes the proliferation of embryonic neural stem cells, enhances hippocampal neurogenesis and learning and memory abilities in adult mice

BACKGROUND AND PURPOSE: Fingolimod (FTY‐720) is the first oral therapeutic drug approved for the relapsing–remitting forms of multiple sclerosis. Neural stem cells (NSCs) are capable of continuous self‐renewal and differentiation. The dentate gyrus of the hippocampus in the adult mammalian brain con...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Sun, Yili, Hong, Feng, Zhang, Lei, Feng, Linyin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995289/
https://ncbi.nlm.nih.gov/pubmed/27429358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13557
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