Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83

Deficiency of CD83 in thymic epithelial cells (TECs) dramatically impairs thymic CD4 T cell selection. CD83 can exert cell-intrinsic and –extrinsic functions through discrete protein domains, but it remains unclear how CD83’s capacity to operate through these alternative functional modules relates t...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: von Rohrscheidt, Julia, Petrozziello, Elisabetta, Nedjic, Jelena, Federle, Christine, Krzyzak, Lena, Ploegh, Hidde L., Ishido, Satoshi, Steinkasserer, Alexander, Klein, Ludger
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995086/
https://ncbi.nlm.nih.gov/pubmed/27503071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160316
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