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The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts
BACKGROUND: Colon and intestinal crypts serve as an important model system for adult stem cell proliferation and differentiation. We develop a spatial stochastic model to study the rate of somatic evolution in a normal crypt, focusing on the production of two-hit mutants that inactivate a tumor supp...
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| Publicado no: | Biol Direct |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4994304/ https://ncbi.nlm.nih.gov/pubmed/27549762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13062-016-0141-6 |
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