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Cytotoxic and targeted therapy for hereditary cancers

There is a number of drugs demonstrating specific activity towards hereditary cancers. For example, tumors in BRCA1/2 mutation carriers usually arise via somatic inactivation of the remaining BRCA allele, which makes them particularly sensitive to platinum-based drugs, PARP inhibitors (PARPi), mitom...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Hered Cancer Clin Pract
Hauptverfasser: Iyevleva, Aglaya G., Imyanitov, Evgeny N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994296/
https://ncbi.nlm.nih.gov/pubmed/27555886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13053-016-0057-2
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