Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model

Parkinson’s disease is one of the most common neurodegenerative disorders of the elderly and ageing hence described to be a major risk factor. Telomere shortening as a result of the inability to fully replicate the ends of linear chromosomes is one of the hallmarks of ageing. The role of telomere dy...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Neuropathol Commun
Auteurs principaux: Scheffold, Annika, Holtman, Inge R., Dieni, Sandra, Brouwer, Nieske, Katz, Sarah-Fee, Jebaraj, Billy Michael Chelliah, Kahle, Philipp J., Hengerer, Bastian, Lechel, André, Stilgenbauer, Stephan, Boddeke, Erik W. G. M., Eggen, Bart J. L., Rudolph, Karl-Lenhard, Biber, Knut
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994259/
https://ncbi.nlm.nih.gov/pubmed/27550225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0364-x
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