Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

BACKGROUND: The fractalkine (CX3CR1) ligand is expressed in astrocytes and reported to be neuroprotective. When cleaved from the membrane, soluble fractalkine (sCX3CL1) activates the receptor CX3CR1. Although somewhat controversial, CX3CR1 is reported to be expressed in neurons and microglia. The me...

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Udgivet i:J Neuroinflammation
Main Authors: O’Sullivan, Sinead A., Gasparini, Fabrizio, Mir, Anis K., Dev, Kumlesh K.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994207/
https://ncbi.nlm.nih.gov/pubmed/27549131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0659-7
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