Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen.

The autoimmune phenomena associated with destruction of the beta cell in pancreatic islets and development of type 1 (insulin-dependent) diabetes mellitus (IDDM) include circulating islet cell antibodies. We have immortalized peripheral blood lymphocytes from prediabetic individuals and patients wit...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Richter, W, Endl, J, Eiermann, T H, Brandt, M, Kientsch-Engel, R, Thivolet, C, Jungfer, H, Scherbaum, W A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49941/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1382289/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.18.8467
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