Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

[Image: see text] Many oncogenic mutants of the tumor suppressor p53 are conformationally unstable, including the frequently occurring Y220C mutant. We have previously developed several small-molecule stabilizers of this mutant. One of these molecules, PhiKan083, 1-(9-ethyl-9H-carbazole-3-yl)-N-meth...

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Détails bibliographiques
Publié dans:ACS Chem Biol
Auteurs principaux: Bauer, Matthias R., Jones, Rhiannon N., Baud, Matthias G. J., Wilcken, Rainer, Boeckler, Frank M., Fersht, Alan R., Joerger, Andreas C., Spencer, John
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2016
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994063/
https://ncbi.nlm.nih.gov/pubmed/27267810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00315
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